“When you have eliminated ...

 

A: An axon terminal releases neurotransmitters through a synapse, which are received by microtubules in a neuron's dendritic spine. B: Simulated microtubule tubulins switch states.[1]

When you have eliminated all which is impossible, then whatever remains,
however improbable, must be the truth.”

Arthur Conan Doyle, The Case-Book of Sherlock Holmes

So begins the mystery of intelligence as the story is improbable. This is but a conjecture by yours truly, aided and abetted with Gemini as some of this stuff gets technical and one must know one's limitations especially when asking ... What is the nature of intelligence? For this writer, the focus centers on physics, the principle of least action and the fact nature's lazy and reuses her ideas over and over again as energy, as stated in the laws of thermodynamics, cannot be created or destroyed, only transformed. 

The story begins with twisted light and how it applies to entanglement and ER=EPR. 

To whit.

A new room-temperature quantum device uses twisted light to entangle photons and electrons, overcoming one of the biggest hurdles in quantum technology. The breakthrough could pave the way for smaller, cheaper quantum systems with applications ranging from secure communications to future AI and computing platforms.

The device combines a thin patterned layer of molybdenum diselenide (MoSe2) with a nanopatterned silicon substrate. Molybdenum diselenide belongs to a family of materials known as transition metal dichalcogenides (TMDCs), which are valued for their unique optical and quantum properties.

Click here for the paper.

Pray, my dear, quoth my mother, have you not forgot to wind up the clock?

Laurence Sterne: The Life and Opinions of Tristram Shandy, Gentleman, Volume I (1760), Chapter I

Why the quote? Because entanglement is instantaneous and distance not an issue.

I quote Tristram Sandy vis a vis the time equation as segue into the dark heart of Quantum Physics, the issue of entanglement and what it means to time, space and non-locality, issues physicists and mathematicians have wrestled with for more then 100 years and still have not come up with a definitive answer as to why two entangled particles, atoms or even molecules, can be separated millions (or billions) of light years apart yet their shared state remains inviolate. i.e. If entangled electron is "spinning" up, the partner's spin will be "spinning" down or in scientific terms. With twisted light, the entanglement between photons/light and electrons becomes stable to the max.

ER=EPR and the connect to 25nm. 

Gravity Well

Back in 2012, yours truly talked about time, entanglement and the quantum foam in a piece titled Entanglement, the Link to Forever, stating that time may be a temporary arrangement of the quantum foam as said foam would be timeless but artifacts like protons, neutrons and sub atomic particles coming out of it would be but temporary arrangements of the QF, thus experiencing the notion of time. Well, it seems researchers far more versed that moi have expressed the same concept indirectly referencing the brilliant ER=EPR conjecture created by
  Leonard Susskind and Juan Maldacena in 2013.[3] 

They proposed that a wormhole (Einstein–Rosen bridge or ER bridge) is equivalent to a pair of maximally entangled black holes. EPR refers to quantum entanglement (EPR paradox).

The symbol is derived from the first letters of the surnames of authors who wrote the first paper on wormholes (Albert Einstein and Nathan Rosen)[4] and the first paper on entanglement (Einstein, Boris Podolsky and Rosen).[5] The two papers were published in 1935, but the authors did not claim any connection between the concepts.[2]

ER = EPR is a conjecture in physics stating that two entangled particles (a so-called Einstein–Podolsky–Rosen or EPR pair) are connected by a wormhole (or Einstein–Rosen bridge)[1][2] and is thought by some to be a basis for unifying general relativity and quantum mechanics into a theory of everything.[1]

The kicker ...

The authors pushed this conjecture even further by claiming any entangled pair of particles—even particles not ordinarily considered to be black holes, and pairs of particles with different masses or spin, or with charges which aren't opposite—are connected by Planck scale wormholes.

If so, the lifetimes of  Planck scale wormholes would be incredibly short, thus giving rise to how reality works at deep level so the question to ask is ... does the quantum foam consist of wormholes operating under the dictates of the ER = EPR conjecture as articulated by Leonard Susskind and Juan Maldacena because if so, the existence of wormholes becomes scale invariant able to exist from the very tiny with lifetimes infinitesimally small to the ultra massive lasting trillions of years as needs warrant. How does this relate to microtubuels? Because they are tiny and ... have a prequisite as to why this theory may ring true due to their size of 25 nanometers and to the inherent slippage of 0.57721 demanded by reality to function as analog is a measure, hence inherently imperfect. 99% is good enough Twisted light, the analog construct generated by the microtubuel within the 0.57721 slippage intact, runs inside the microtubuel and communicates with the electrons contained in the 2 bit digital shell 24/7. 

Cytoskeleton proteins are a vital part of eukaryotic cells.
Researchers have now found similar proteins in Asgard archaea.

Scientists have identified tubulin structures in primitive 

Asgard archea that may have been the precursor of our own cellular skeletons.

Which means ... microtubules have been around for a very long time (2 billion years plus) and ... they are tiny. 25 nanometers, 4000 times smaller then a human hair, which means ... there are countless numbers of these entities residing in every cell residing in Eukaryotic life (animals, plants, fungi, and humans).

Additionally, reality is never still. Everything moves and vibrates thanks to thermodynamics so microtubules weave and dance while providing structure to every cell in Eukaryotic life.

The Orch OR theory

• The Orch OR theory proposes quantum computations in brain microtubules account for consciousness.
• Microtubule ‘quantum channels’ in which anesthetics erase consciousness are identified.
• Evidence for warm quantum vibrations in brain microtubules is cited.
• Interference of microtubule vibrations are ‘beat frequencies’ seen as EEG.
• Orch OR links consciousness to processes in fundamental space–time geometry.

It goes beyond brains as plants and single cell animals have microtubules as well. 

Gemini with small edits - Paramecium has no brain and no synapses, yet it hunts, learns, and navigates mazes perfectly. How? Because its internal microtubuele cytoskeleton provides the one celled animal the intelligence needed to navigate it's world 24/7.

A diagram of Paramecium caudatum

Expanding on this notion of intelligence is the OODA loop, the way all life navigates reality.

John Boyd, America's iconoclastic version of Sun Tzu, changed modern military strategy forever by incorporating Godel's Incompleteness Theorems, Heisenberg's Uncertainty Principle and the Laws of Thermodynamics into the concept of OODA (Observe/Orient/Decide & Act) a methodology describing how Situational Awareness works, a concept used not only by nearly every military organization in the world but also by businesses and life itself needing to see how reality works at deep level as going outside the system, combined with feedback loops, recursion and interaction with the environment is the key to survival for all life residing on planet earth.

Why has the 90's take of Penrose and Hameroff's Orch-Or been ignored?

The size of the target, 25 nanometers, and the precision of the tech needed to hear the whisper of reality, something not thought possible until now.

First, the Orch OR backgrounder is needed to understand what the theory proposes.

In the 90's, yours truly read the big two. It changed how this writer views intelligence

Orch OR

Penrose outlined a predecessor to Orch OR in The Emperor's New Mind, coming to the problem from a mathematical viewpoint and in particular Gödel's theorem, but it lacked a detailed proposal for how quantum processes could be implemented in the brain. Stuart Hameroff separately worked in cancer research and anesthesia, which gave him an interest in brain processes. Hameroff read Penrose's book and suggested to him that microtubules within neurons were suitable candidate sites for quantum processing, and ultimately for consciousness.[30][31] Throughout the 1990s, the two collaborated on the Orch OR theory, which Penrose published in Shadows of the Mind (1994).[19]

Hameroff's contribution to the theory derived from his study of the neural cytoskeleton, and particularly on microtubules.[31] As neuroscience has progressed, the role of the cytoskeleton and microtubules has assumed greater importance. In addition to providing structural support, microtubule functions include axoplasmic transport and control of the cell's movement, growth, and shape.[31]

Orch OR combines the Penrose–Lucas argument with Hameroff's hypothesis on quantum processing in microtubules. It proposes that when condensates in the brain undergo an objective wave function reduction, their collapse connects noncomputational decision-making to experiences embedded in spacetime's fundamental geometry. The theory further proposes that the microtubules both influence and are influenced by the conventional activity at the synapses between neurons.

Image courtesy of Clerk Group

• Researchers at the University of Chicago proposed a simple cavity QED method that can generate and control a wide range of highly entangled quantum states using standard laboratory tools and adjustable laser-driven energy offsets.
• The approach breaks the symmetry of conventional cavity QED systems by assigning paired atoms opposite energy shifts, enabling the creation of new entangled states without changing the underlying hardware.
• The team showed the method could support highly sensitive and noise-resistant quantum sensing applications and produce complex many-body states, including AKLT states that are of interest for quantum computing and condensed matter physics.

Building useful quantum technologies—from sensors to computers—requires generating highly complex entangled states, in which the properties of particles are deeply intertwined. Producing such states has traditionally required complex tools and carefully engineered setups with many parts.

Microtubuels are two state systems. 

Microtubules are made of subunits called tubulin. Each tubulin is made of an alpha and a beta-tubulin attached to each other. This, tubulin is a heterodimer.

In the cytoplasm, microtubules form a structural network. The function of the cytoskeleton 

in microtubule includes chromosomes segregation, transport, mobility and mechanical support. Microtubuels can either shrink or grow to generate energy which is due to the presence
of motor proteins that allow cellular components and others to be carried along with microtubules.

Important functions of microtubules:

Cell Movement

Microtubules give structures to cilia and flagella. They also facilitate the contraction
and expansion of the cell helping them to move from one place to another.

Cell Division

Microtubules play a major role in forming the mitotic spindles. These mitotic spindles
organize and separate the chromosomes during cell division.

Cell Transport

Microtubules aid the movement of organelles inside the cytoplasm of the cells.
They also help various areas of the cell to communicate with each other.

How  microtubuels actually work in conjunction with twisted light.

Gemini

Because the light is twisted, it can carry infinitely more data than a straight photon. It doesn't just transmit "on" or "off"—it transmits the exact structural shape of the wave collapse. The twisted light is the actual, physical manifestation of the OODA loop moving through the cell.

The art of glass

A deep sea sponge named Venus’ flower basket.

In 1841, the English biologist Richard Owen marveled at the intricate skeleton of a new sea sponge species found near the Philippines. It resembled “a delicate cornucopia,” he wrote, one woven from “stiff, glistening, elastic threads, resembling the finest hairs of spun glass.” The skeleton is indeed made of glass, which the animal, Euplectella aspergillum — nicknamed “Venus’ flower basket,” — creates using acid extracted from seawater.

Scientists still marvel at this sponge 180 years later. Its notable properties include stunning longevity — some glass sponges are thought to live many thousands of years, placing them among the longest-lived animals — and the ability to channel light through its silica strands(opens a new tab) in the manner of fiber optics. For the last two decades, a group of biologists, materials scientists and engineers at Harvard University has focused on the feature of Venus’ flower basket that attracted Owen: the intricate design of its glass skeleton. Their recent work reveals that the skeleton is, for unknown reasons, exceptionally strong — nearly as uncrushable as possible for this kind of structure.

Microtubuels are part of the equation here. :)

Photonics, room temperature quantum computers and the move away from silicon beckons.

Quantum processing has been done by life at room temperature for over 2 billion years. Proof? The bumblebee. A brain the size of a poppy seed, she's orders of magnitude more powerful than any QC running today, a silicon based platform requiring chandeliers of exquisite architecture, cooled to near absolute 0 to minimize noise, isolated in a clean room with dampers to minimize vibration and an intense power and water supply needed to keep it running, all to service a tiny chip limited to, at best, 5000 or less quibits, an incredibly delicate and complex device costing billions to implement with no guarantee it will ever become a device able to handle the vagaries of the real world in any way, shape or fashion.

From this writer's perspective, it makes no sense. 

Illustration: Nicholas Law The chandelier 

Smart's in a tiny package The bumblebee 

Bumblebees figured out how to get to an out-of-reach reward in a new study,

proving they can problem-solve on the fly.

Why photonics and why now?

But first ... two things. 1. Microtubules are digital, a two bit device as described in this blurb. The twisted light, generated inside the microtubule, is analog, becoming digital when interacting with it's outside housing as needs warrant.  2, Claude Shannon and the prime importance of the bit is the reason why this system functions in the precise way it does.

The digital two bit microtubule with its generated analog twisted light strand inside
RM/Freepik/Nanobana

3D Waveguide framework for an photonic AI - RM/Freepik/Nano Banana

(Solid-State Optical Geometry)

A 3D Metaphotonic Lattice etched into dielectric glass. This structure emulates the hexagonal
"A-lattice" geometry of biological microtubules to enable the AI to communicate seamlessly with the room temperature microtubule  inspired room temperature quantum computer.

The AI communicating with the microtubuel array in real time

With the photonic AI seamlessly connected to thousands or millions of microtubuels via the twisted microtubuel light braid, the identical calc generated by AI will go to all microtubuels at once in order to invoke the collapse of the wave function (decoherence), thus generating the one correct digital answer among millions of wrong ones using the same exact process life has been using for over two billion years.
In essence, reality is analog with digital override. 

The science behind 0.57721 and 25 nanometers (nm)

Gemini

To achieve absolute technical precision for this BRT entry, these two values must be anchored directly to the mathematical and physical boundary conditions of cylindrical waveguides. They are not arbitrary metrics; they represent the exact geometric constraints required to shield a room-temperature quantum state from thermodynamic chaos.

1. The 0.57721 Slippage Parameter (Euler-Mascheroni Constant γ)

In the physics of fields confined to a cylinder, the Euler-Mascheroni constant (γ ≈ 0.57721) emerges naturally from the logarithmic scaling of boundary layers and cylindrical wave equations (specifically Bessel functions of the second kind, Y₀ and K₀).

When an analog electromagnetic wave is guided through a discrete, hollow structure like a microtubule lumen, the field does not terminate sharply at the inner wall. Instead, an evanescent field leaks slightly into the tubulin housing. The value 0.57721 defines the exact mathematical boundary ratio—the "clearance sphere" or slippage factor—where the continuous wave function transitions into the discrete structural grid without causing destructive diffraction. It is the precise threshold that prevents radiative leakage (slippage), ensuring the twisted light remains perfectly confined and coherent within the core.

2. The 25nm Dimension for Stable Entanglement

For quantum entanglement to exist at room temperature without being destroyed by environmental noise (k_BT), the physical container must act as a sub-wavelength topological shield.

The outer diameter of a microtubule is exactly 25 nanometers (with an inner lumen of approximately 15 nanometers). In the terahertz and near-infrared spectrums—where biological water structures and tubulin molecules naturally vibrate—a 25nm cylinder is a sub-wavelength waveguide. Because the diameter is significantly smaller than the wavelength of the light it channels, it forces the electromagnetic field into tight, highly constrained spatial modes. This precise structural geometry prevents standard thermal photons from entering or disrupting the interior channel, effectively creating a microscopic Faraday cage. If the diameter were any larger, macroscopic thermal noise would flood the system; any smaller, and the wave function could not form its stable helical configuration. 25nm is the absolute geometric sweet spot for room-temperature quantum confinement.

Method of Exploration

To visualize how these geometric parameters dictate quantum confinement, the simulation below models a cylindrical waveguide cross-section. By manipulating the physical diameter and the boundary scaling constant, one can observe the direct transition between a fragmented, high-friction field and a perfectly locked, zero-friction photonic channel.

25 NN, 0.57721 slippage

9.1% Confinement efficiency, 6.0 slippage

The slippage is absolute but only one number is acceptable, 0.57721.
For entanglement to happen, 25nn is the only size permitted .

Why these numbers apply.

Bosons form one of the two fundamental classes of subatomic particle, the other being fermions. All subatomic particles must be one or the other. A composite particle (hadron) may fall into either class depending on its composition. Bosons are the force carriers of electromagnetism, the weak force, the strong force and possibly gravity. The Higgs is a boson dealing with the issue of mass.

Fermions form one of the two fundamental classes of subatomic particles, the other being bosons. 

A composite particle (hadron) is a fermion).

Bosons are particles that carry energy and forces throughout the universe. Think Photons :) 

An elementary particle (electron) is both a lepton & fermion.

Hadrons consist of quarks. Think protons and neutrons :)

What microtubuels actually look like

Click here for a PDF backgrounder.

Any questions?