Out, out, brief candle!

A naked mole rat is pictured at the University of Rochester January 31, 2018. J. Adam Fenster/University of Rochester

The poster child for longevity is the naked mole rat as said rodent, unlike his above ground cousins, lives for 30+ years due to unique body chemistry researchers are trying to leverage in order to increase the life spans of us rubes.

Gorbunova traces much of the hardiness of the mole rats to an abundance of hyaluronic acid, a major component of skin that is involved in tissue regeneration. Although mice and humans also have hyaluronic acid, the tissues of naked mole rats are "saturated with it," says Gorbunova. In addition to having strong antioxidant properties, and others that seem to attenuate the destructive consequences of the chronic, widespread inflammation that often accumulates with age, the abundance of hyaluronan also seems to prevent the growth of malignant cancer cells.

"Hyaluronan is a very nice story because we can see the possibility of translating it to humans," Gorbunova says. "We have it, but we don't have a lot of it, so I think there is room for improvement. We can find ways to increase our own levels of hyaluronan."

It gets better

To Gorbunova, the differences between the mouse and naked mole rat are easily explained by evolution—their respective adaptations are geared toward increasing their chances of reproductive success. "For a mouse, the best strategy to have more progeny is to be very, very prolific very quickly because then somebody's going to eat it, and it just doesn't have a chance to live longer," she explains. "The naked mole rat lives underground and has very few predators. And they breed until very late in life. So they would evolve the mechanism to allow them to live longer and to breathe as long as possible just because they can. No one is there to eat them. And the longer they live the more progeny they have."

Billions are being spent to find the fountain of youth using age and not disease as start point as aging leads to diseases like cancer and cardiovascular without question.

The same logic applies to humans—and it also explains why our bodies fall apart. Diseases of aging, many gerontologists now argue, are the natural consequence of the advances in modern lifespan, which now extends decades past reproductive age, and thus has not been subject to the same exquisitely efficient evolutionary sculpting that might increase our odds of surviving them. "If you put this work in an evolutionary perspective, we were not supposed to live that long," says Gerard Karsenty, who chairs the Department of Genetics and Development at Columbia University Medical Center. "Aging is an invention of mankind. No animal species has successfully cheated its own body—cheated nature—except mankind. Elephants may live for 100 years but they lived for 100 years a million years ago. Humans have outsmarted their own body."

Truer words never spoken. Read the detailed Newsweek piece to see why this statement rings true. 

Tomorrow, and tomorrow, and tomorrow,

Creeps in this petty pace from day to day,

To the last syllable of recorded time;

And all our yesterdays have lighted fools

The way to dusty death. Out, out, brief candle!

Life's but a walking shadow, a poor player,

That struts and frets his hour upon the stage,

And then is heard no more. It is a tale

Told by an idiot, full of sound and fury,

Signifying nothing.